|
KMID : 1143420200130302216
|
|
Public Health Weekly Report
2020 Volume.13 No. 30 p.2216 ~ p.2225
|
|
|
Laboratory-based diagnosis of Japanese encephalitis in Korea, 2017-2019
|
|
Lee Eun-Jung
Lee Hyeok-Jin
Lim A-Ram
Choi Woo-Young
Han Myung-Guk
|
|
|
Abstract
|
|
|
|
Japanese encephalitis virus (JEV), a mosquito-borne zoonotic pathogen, is one of the major causes of viral encephalitis. JEV is divided into five genotypes (genotype I, II, III, IV, V), based on the nucleotide sequence of the envelope gene. Three genotypes (I, III, V) of JEV were confirmed in Korea. Japanese encephalitis (JE) laboratory tests include real-time RT-PCR polymerase chain reaction assay (RT-PCR), antibody detection tests such as enzyme immunoassay (IgM ELISA), indirect immunofluorescence assay (IFA), plaque reduction neutralization test (PRNT), and virus isolation in cell culture in serum and cerebrospinal fluid tests. The aim of this study was to report on the status of JE in Korea from 2017 to 2019. Findings indicated that from 2017, the number of JE cases doubled every year, and by 2019, a total of 60 cases had occurred, of which 9 had died of JE. Findings also indicated that most cases occurred in Seoul, a large metropolitan city, and Gyeonggi, a large province, and that the majority of the cases were 50 years of age or older. This study also confirmed that JEV cases have typically occurred in September-October in Korea.
|
|
|
KEYWORD
|
|
|
Japanese encephalitis, Japanese encephalitis virus, genotype V, virus isolation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|